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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
26.97
Human Site:
Y476
Identified Species:
42.38
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
Y476
A
I
E
E
L
V
K
Y
Q
L
E
K
T
Q
R
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
Y476
A
I
E
E
L
V
K
Y
Q
L
E
K
T
Q
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
Y476
A
I
E
E
L
V
K
Y
Q
L
E
K
T
Q
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
Y477
A
I
E
E
L
V
K
Y
Q
L
E
K
T
Q
R
Rat
Rattus norvegicus
Q9JIM0
706
80103
Y477
A
I
E
E
L
V
K
Y
Q
L
E
K
T
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
Y477
A
I
E
E
L
V
K
Y
Q
L
E
K
T
Q
R
Chicken
Gallus gallus
Q9IAM7
700
80005
F477
A
I
E
E
L
V
K
F
Q
L
E
K
T
Q
R
Frog
Xenopus laevis
Q9W6K1
711
81112
F479
A
L
E
E
L
V
K
F
Q
L
E
K
T
Q
R
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
H398
A
N
P
K
D
I
L
H
F
V
R
H
R
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
T400
R
F
G
E
M
L
S
T
R
V
A
N
V
Q
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
E492
N
I
T
E
M
A
D
E
M
G
Q
V
S
A
T
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
E298
K
C
T
K
L
K
L
E
T
V
R
P
F
Y
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
L459
F
V
N
K
D
D
K
L
A
F
Y
S
C
V
Q
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
V465
Q
L
S
L
L
P
E
V
G
L
N
E
A
V
K
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
T485
F
V
I
E
S
L
S
T
Q
V
K
E
L
L
Q
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
93.3
86.6
6.6
N.A.
13.3
N.A.
13.3
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
40
N.A.
40
N.A.
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
40
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
60
0
0
0
0
7
0
0
7
0
7
0
7
7
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
0
0
0
0
14
7
7
0
0
0
0
0
0
0
7
% D
% Glu:
0
0
54
74
0
0
7
14
0
0
54
14
0
7
0
% E
% Phe:
14
7
0
0
0
0
0
14
7
7
0
0
7
0
0
% F
% Gly:
0
0
7
0
0
0
0
0
7
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
7
0
0
0
% H
% Ile:
0
54
7
0
0
7
0
0
0
0
0
0
0
0
7
% I
% Lys:
7
0
0
20
0
7
60
0
0
0
7
54
0
0
7
% K
% Leu:
0
14
0
7
67
14
14
7
0
60
0
0
7
7
0
% L
% Met:
0
0
0
0
14
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
7
7
7
0
0
0
0
0
0
0
7
7
0
0
0
% N
% Pro:
0
0
7
0
0
7
0
0
0
0
0
7
0
0
0
% P
% Gln:
7
0
0
0
0
0
0
0
60
0
7
0
0
60
14
% Q
% Arg:
7
0
0
0
0
0
0
0
7
0
14
0
7
0
54
% R
% Ser:
0
0
7
0
7
0
14
0
0
0
0
7
7
0
0
% S
% Thr:
0
0
14
0
0
0
0
14
7
0
0
0
54
0
14
% T
% Val:
0
14
0
0
0
54
0
7
0
27
0
7
7
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
40
0
0
7
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _